Supplementary Figures S1-S8 from Novel Morphologic and Genetic Analysis of Cancer Cells in a 3D Microenvironment Identifies STAT3 as a Regulator of Tumor Permeability Barrier Function

Supplementary Figure S1. Characterization of cancer spheroids. Supplementary Figure S2. Characteristics of spheroids based on morphologic classification. Supplementary Figure S3. Validation of spheroid morphology-dependent characteristics. Supplementary Figure S4. Validation of PLS-DA model. Supplementary Figure S5. Network models describing cellular processes associated with spheroid subtypes. Supplementary Figure S6. Drug penetration test in spheroids using bimolecular fluorescence complementation (BiFC). Supplementary Figure S7. Molecular signature of GBM patient-derived round type spheroid. Supplementary Figure S8. Xenograft model to validate JAK-STAT pathway for drug sensitivity.