posted on 2023-04-03, 15:08authored byNicholas Forsythe, Alaa Refaat, Arman Javadi, Hajrah Khawaja, Jessica-Anne Weir, Heba Emam, Wendy L. Allen, Frank Burkamp, Vlad Popovici, Puthen V. Jithesh, Claudio Isella, Melissa J. Labonte, Ian G. Mills, Patrick G. Johnston, Sandra Van Schaeybroeck
Figure S1: Discovery and validation datasets used in the study; Figure S2: Sensitivity of BRAFMT and WT CRC cells to acute ER stress induction; Figure S3: Sensitivity of BRAFMT and WT CRC cells to ACY-1215 and carfilzomib; Figure S4: Effect of combined ACY-1215 and carfilzomib on survival of BRAFMT and WT CRC cells; Figure S5: Effect of combined ACY-1215 and carfilzomib on accumulation of ubiquitinated proteins; Figure S6: Tolerability of combined ACY-1215/carfilzomib treatment in BALB/c nude mice