Supplementary Figures 5-6 from VEGF-PET Imaging Is a Noninvasive Biomarker Showing Differential Changes in the Tumor during Sunitinib Treatment

Nagengast, Wouter B.; Lub-de Hooge, Marjolijn N.; Oosting, Sjoukje F.; den Dunnen, Wilfred F.A.; Warnders, Frank-Jan; Brouwers, Adrienne H.; de Jong, Johan R.; Price, Patricia M.; Hollema, Harry; Hospers, Geke A.P.; Elsinga, Philip H.; Hesselink, Jan Willem; Gietema, Jourik A.; de Vries, Elisabeth G.E.

doi:10.1158/0008-5472.22385888.v1

00085472can101088-sup-sfigs_5-6.pdf (193.87 kB)

Supplementary Figures 5-6 from VEGF-PET Imaging Is a Noninvasive Biomarker Showing Differential Changes in the Tumor during Sunitinib Treatment

journal contribution

posted on 2023-03-30, 20:02 authored by Wouter B. Nagengast, Marjolijn N. Lub-de Hooge, Sjoukje F. Oosting, Wilfred F.A. den Dunnen, Frank-Jan Warnders, Adrienne H. Brouwers, Johan R. de Jong, Patricia M. Price, Harry Hollema, Geke A.P. Hospers, Philip H. Elsinga, Jan Willem Hesselink, Jourik A. Gietema, Elisabeth G.E. de Vries

Supplementary Figures 5-6 from VEGF-PET Imaging Is a Noninvasive Biomarker Showing Differential Changes in the Tumor during Sunitinib Treatment

History

ARTICLE ABSTRACT

Non-invasive imaging of angiogenesis could ease the optimization of antiangiogenesis treatments for cancer. In this study, we evaluated the role of VEGF-PET as a biomarker of dynamic angiogenic changes in tumors following treatment with the kinase inhibitor sunitinib. The effects of sunitinib treatment and withdrawal on the tumor was investigated using the new VEGF-PET tracer 89Zr-ranibizumab as well as 18F-FDG PET, and 15O-water PET in mouse xenograft models of human cancer. The obtained imaging results were compared with tumor growth, VEGF plasma levels and immunohistologic analyzes. In contrast to 18F-FDG and 15O-water PET, VEGF-PET demonstrated dynamic changes during sunitinib treatment within the tumor with a strong decline in signal in the tumor center and only minimal reduction in tumor rim, with a pronounced rebound after sunitinib discontinuation. VEGF-PET results corresponded with tumor growth and immunohistochemical vascular- and tumor- markers. Our findings highlight the strengths of VEGF-PET imaging to allow serial analysis of angiogenic changes in different areas within a tumor. Cancer Res; 71(1); 143–53. ©2010 AACR.