Supplementary Figures 1 through 7 and Supplementary Tables 1 and 2 from <i>TET2</i> Mutations Affect Non-CpG Island DNA Methylation at Enhancers and Transcription Factor–Binding Sites in Chronic Myelomonocytic Leukemia

<p>7 supplementary figures, and 2 supplementary tables. Supplementary Figure 1. Scatter plots for DNA methylation levels analyzed by DREAM. Supplementary Figure 2. Difference in DNA methylation for 7 repeat classes by bisulphite-pyrosequencing for TET2-MT, TET2-WT cases, and normal blood samples. Supplementary Figure 3. Unsupervised hierarchical analyses for DNA methylation levels for all sites analyzed by DREAM. Supplementary Figure 4. Supervised hierarchical analysis for DNA methylation levels for tet2-DMCs. Supplementary Figure 5. Representative genomic landscapes for tet2-DMCs more methylated in TET2-MT in NCGIs. Supplementary Figure 6. Bar plots for the enrichment of tet2-DMCs in NCGI for regulatory including promoter flanking regions, promoters, enhancers, and CTCF binding sites defined by Ensembl Regulatory Build data. Supplementary Figure 7. p300-related genes are deregulated in TET2-MT. Supplementary Table 1. Primer sequences Supplementary Table 2. Number of unique usable tags obtained from DREAM</p>