Supplementary Figures 1 - 3 from RICTOR Amplification Defines a Novel Subset of Patients with Lung Cancer Who May Benefit from Treatment with mTORC1/2 Inhibitors
posted on 2023-04-03, 21:03authored byHaiying Cheng, Yiyu Zou, Jeffrey S. Ross, Kai Wang, Xuewen Liu, Balazs Halmos, Siraj M. Ali, Huijie Liu, Amit Verma, Cristina Montagna, Abraham Chachoua, Sanjay Goel, Edward L. Schwartz, Changcheng Zhu, Jidong Shan, Yiting Yu, Kira Gritsman, Roman Yelensky, Doron Lipson, Geoff Otto, Matthew Hawryluk, Philip J. Stephens, Vincent A. Miller, Bilal Piperdi, Roman Perez-Soler
Supplementary Figure 1 shows RICTOR amplification/overexpression in the index patient by FISH and IHC. Supplementary Figure 2 shows analysis of TCGA database for RICTOR alteration in all types of cancers, including NSCLC. Supplementary figure 3A shows the gene alterations in each individual with RICTOR-amplified tumors. 3B shows the absolute and relative frequency of each gene alteration found in RICTOR-amplified lung cancer samples from FM NGS database.