Supplementary Figures 1-7 from Genome-Wide Interrogation of Human Cancers Identifies EGLN1 Dependency in Clear Cell Ovarian Cancers

Supplementary Figure 1 identifies EGLN1 as a cancer dependency in RNAi and CRISPR datasets and contains all significant associations. Supplementary Figure 2 is a lineage analysis of EGLN1 dependency within RNAi dataset. Supplementary Figure 3 is an immunoblot showing EGLN1 knockout in EGLN1-insensitive cell line. Supplementary Figure 4 shows pan-EGLN inhibition affects proliferation and apoptosis. Supplementary Figure 5 shows specific EGLN1 inhibitor IOX2 and VHL inhibitor VH298 inhibit proliferation. Supplementary Figure 6 shows differentially expressed genes in EGLN1-KO cells. Supplementary Figure 7 shows increased apoptosis in vivo when inhibiting EGLN1 or VHL.