journal contribution
posted on 2023-03-31, 17:35 authored by Daniel W. Lin, Lisa F. Newcomb, Elissa C. Brown, James D. Brooks, Peter R. Carroll, Ziding Feng, Martin E. Gleave, Raymond S. Lance, Martin G. Sanda, Ian M. Thompson, John T. Wei, Peter S. Nelson <p>PDF - 160K, Supplementary Figure S1. ROC analysis of serum PSA, TMPRSS2:ERG, PCA3, alone and in combination, for prediction of ��34% positive biopsy cores at time of specimen collection. AUC(PSA) does not differ significantly from AUC(TMPRSS2:ERG) P = 0.31, AUC(PCA3) P = 0.21, AUC(TMPRSS2:ERG +PCA3) P = 0.21, or AUC(TMPRSS2:ERG +PCA3+PSA) P = 0.24. Supplementary Figure S2. Multivariable logistic regression analysis for the prediction of high Gleason grade (��7) at time of specimen collection. (A) ROC curve and (B) Odds ratios for each covariate. N = 360 Supplementary Figure S3. Multivariable logistic regression analysis for the prediction of high Gleason grade (��7) at time of specimen collection. Participants with an abnormal DRE were excluded. (A) ROC curve and (B) Odds ratios for each covariate. N = 308.</p>
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ARTICLE ABSTRACT
Purpose: Active surveillance is used to manage low-risk prostate cancer. Both PCA3 and TMPRSS2:ERG are promising biomarkers that may be associated with aggressive disease. This study examines the correlation of these biomarkers with higher cancer volume and grade determined at the time of biopsy in an active surveillance cohort.Experimental Design: Urine was collected after digital rectal examination prospectively as part of the multi-institutional Canary Prostate Active Surveillance Study (PASS). PCA3 and TMPRSS2:ERG levels were analyzed in urine collected at study entry. Biomarker scores were correlated to clinical and pathologic variables.Results: In 387 men, both PCA3 and TMPRSS2:ERG scores were significantly associated with higher volume disease. For a negative repeat biopsy, and 1% to 10%, 11% to 33%, 34% or more positive cores, median PCA3, and TMPRSS2:ERG scores increased incrementally (P < 0.005). Both PCA3 and TMPRSS2:ERG scores were also significantly associated with the presence of high-grade disease. For a negative repeat biopsy, Gleason 6 and Gleason ≥7 cancers, the median PCA3, and TMPRSS2:ERG scores also increased incrementally (P = 0.02 and P = 0.001, respectively). Using the marker scores as continuous variables, the ORs for a biopsy in which cancer was detected versus a negative repeat biopsy (ref) on modeling was 1.41 (95% CI: 1.07–1.85), P = 0.01 for PCA3 and 1.28 (95% CI: 1.10–1.49), P = 0.001 for TMPRSS2:ERG.Conclusions: For men on active surveillance, both PCA3 and TMPRSS2:ERG seem to stratify the risk of having aggressive cancer as defined by tumor volume or Gleason score. Clin Cancer Res; 19(9); 2442–50. ©2013 AACR.
