Supplementary Figures 1-2 from Direct Evidence for Epithelial-Mesenchymal Transitions in Breast Cancer

Trimboli, Anthony J.; Fukino, Koichi; de Bruin, Alain; Wei, Guo; Shen, Lei; Tanner, Stephan M.; Creasap, Nicholas; Rosol, Thomas J.; Robinson, Michael L.; Eng, Charis; Ostrowski, Michael C.; Leone, Gustavo

doi:10.1158/0008-5472.22373550.v1

00085472can072148-sup-suppl_figs_1-2.pdf (221.23 kB)

Supplementary Figures 1-2 from Direct Evidence for Epithelial-Mesenchymal Transitions in Breast Cancer

journal contribution

posted on 2023-03-30, 18:02 authored by Anthony J. Trimboli, Koichi Fukino, Alain de Bruin, Guo Wei, Lei Shen, Stephan M. Tanner, Nicholas Creasap, Thomas J. Rosol, Michael L. Robinson, Charis Eng, Michael C. Ostrowski, Gustavo Leone

Supplementary Figures 1-2 from Direct Evidence for Epithelial-Mesenchymal Transitions in Breast Cancer

History

ARTICLE ABSTRACT

We developed stromal- and epithelial-specific cre-transgenic mice to directly visualize epithelial-mesenchymal transition (EMT) during cancer progression in vivo. Using three different oncogene-driven mouse mammary tumor models and cell-fate mapping strategies, we show in vivo evidence for the existence of EMT in breast cancer and show that myc can specifically elicit this process. Hierarchical cluster analysis of genome-wide loss of heterozygosity reveals that the incidence of EMT in invasive human breast carcinomas is rare, but when it occurs it is associated with the amplification of MYC. These data provide the first direct evidence for EMT in breast cancer and suggest that its development is favored by myc-initiated events. [Cancer Res 2008;68(3):937–45]