Supplementary Figure from Cost-Effectiveness of Colorectal Cancer Surveillance in Hodgkin Lymphoma Survivors Treated with Procarbazine and/or Infradiaphragmatic Radiotherapy

Ykema, Berbel L.M.; Gini, Andrea; Rigter, Lisanne S.; Spaander, Manon C.W.; Moons, Leon M.G.; Bisseling, Tanya M.; de Boer, Jan Paul; Verbeek, Wieke H.M.; Lugtenburg, Pieternella J.; Janus, Cecile P.M.; Petersen, Eefke J.; Roesink, Judith M.; van der Maazen, Richard W.M.; Aleman, Berthe M.P.; Meijer, Gerrit A.; van Leeuwen, Flora E.; Snaebjornsson, Petur; Carvalho, Beatriz; van Leerdam, Monique E.; Lansdorp-Vogelaar, Iris

doi:10.1158/1055-9965.23099403.v1

epi-22-0019_supplementary_figure_2_suppsf2.docx (40.52 kB)

Supplementary Figure from Cost-Effectiveness of Colorectal Cancer Surveillance in Hodgkin Lymphoma Survivors Treated with Procarbazine and/or Infradiaphragmatic Radiotherapy

journal contribution

posted on 2023-05-23, 14:00 authored by Berbel L.M. Ykema, Andrea Gini, Lisanne S. Rigter, Manon C.W. Spaander, Leon M.G. Moons, Tanya M. Bisseling, Jan Paul de Boer, Wieke H.M. Verbeek, Pieternella J. Lugtenburg, Cecile P.M. Janus, Eefke J. Petersen, Judith M. Roesink, Richard W.M. van der Maazen, Berthe M.P. Aleman, Gerrit A. Meijer, Flora E. van Leeuwen, Petur Snaebjornsson, Beatriz Carvalho, Monique E. van Leerdam, Iris Lansdorp-Vogelaar

Supplementary Figure from Cost-Effectiveness of Colorectal Cancer Surveillance in Hodgkin Lymphoma Survivors Treated with Procarbazine and/or Infradiaphragmatic Radiotherapy

Funding

Erasmus Universiteit Rotterdam (EUR)

History

ARTICLE ABSTRACT

Hodgkin lymphoma survivors treated with infradiaphragmatic radiotherapy (IRT) and/or procarbazine have an increased risk of developing colorectal cancer. We investigated the cost-effectiveness of colorectal cancer surveillance in Dutch Hodgkin lymphoma survivors to determine the optimal surveillance strategy for different Hodgkin lymphoma subgroups. The Microsimulation Screening Analysis-Colon model was adjusted to reflect colorectal cancer and other-cause mortality risk in Hodgkin lymphoma survivors. Ninety colorectal cancer surveillance strategies were evaluated varying in starting and stopping age, interval, and modality [colonoscopy, fecal immunochemical test (FIT, OC-Sensor; cutoffs: 10/20/47 μg Hb/g feces), and multi-target stool DNA test (Cologuard)]. Analyses were also stratified per primary treatment (IRT and procarbazine or procarbazine without IRT). Colorectal cancer deaths averted (compared with no surveillance) and incremental cost-effectiveness ratios (ICER) were primary outcomes. The optimal surveillance strategy was identified assuming a willingness-to-pay threshold of €20,000 per life-years gained (LYG). Overall, the optimal surveillance strategy was annual FIT (47 μg) from age 45 to 70 years, which might avert 70% of colorectal cancer deaths in Hodgkin lymphoma survivors (compared with no surveillance; ICER:€18,000/LYG). The optimal surveillance strategy in Hodgkin lymphoma survivors treated with procarbazine without IRT was biennial FIT (47 μg) from age 45 to 70 years (colorectal cancer mortality averted 56%; ICER:€15,000/LYG), and when treated with IRT and procarbazine, annual FIT (47 μg) surveillance from age 40 to 70 was most cost-effective (colorectal cancer mortality averted 75%; ICER:€13,000/LYG). Colorectal cancer surveillance in Hodgkin lymphoma survivors is cost-effective and should commence earlier than screening occurs in population screening programs. For all subgroups, FIT surveillance was the most cost-effective strategy. Colorectal cancer surveillance should be implemented in Hodgkin lymphoma survivors.