Supplementary Figure SF4 from Antibody Binding and Neutralization of Live SARS-CoV-2 Variants Including BA.4/5 Following Booster Vaccination of Patients with B-cell Malignancies

Chang, Andres; Akhtar, Akil; Lai, Lilin; Orellana-Noia, Victor M.; Linderman, Susanne L.; McCook-Veal, Ashley A.; Switchenko, Jeffrey M.; Saini, Manpreet; Valanparambil, Rajesh M.; Blum, Kristie A.; Allen, Pamela B.; Lechowicz, Mary Jo; Romancik, Jason T.; Ayers, Amy; Leal, Alyssa; O'Leary, Colin B.; Churnetski, Michael C.; Baird, Katelin; Kives, Melissa; Wrammert, Jens; Nooka, Ajay K.; Koff, Jean L.; Dhodapkar, Madhav V.; Suthar, Mehul S.; Cohen, Jonathon B.; Ahmed, Rafi

doi:10.1158/2767-9764.22546029.v1

crc-22-0471-s07.pdf (365.55 kB)

Supplementary Figure SF4 from Antibody Binding and Neutralization of Live SARS-CoV-2 Variants Including BA.4/5 Following Booster Vaccination of Patients with B-cell Malignancies

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posted on 2023-04-04, 02:01 authored by Andres Chang, Akil Akhtar, Lilin Lai, Victor M. Orellana-Noia, Susanne L. Linderman, Ashley A. McCook-Veal, Jeffrey M. Switchenko, Manpreet Saini, Rajesh M. Valanparambil, Kristie A. Blum, Pamela B. Allen, Mary Jo Lechowicz, Jason T. Romancik, Amy Ayers, Alyssa Leal, Colin B. O'Leary, Michael C. Churnetski, Katelin Baird, Melissa Kives, Jens Wrammert, Ajay K. Nooka, Jean L. Koff, Madhav V. Dhodapkar, Mehul S. Suthar, Jonathon B. Cohen, Rafi Ahmed

Supplemental Figure 4. Anti-spike binding IgG titers after booster correlate with conventional B cell numbers in the blood prior booster.

Funding

HHS | National Institutes of Health (NIH)

EU | Winship Cancer Institute (Winship Cancer Institute of Emory University)

American Society of Hematology (ASH)

Leukemia and Lymphoma Society (LLS)

EU | School of Medicine, Emory University (Emory University School of Medicine)

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ARTICLE ABSTRACT

Limited data exist on antibody responses against current SARS-CoV-2 variants after booster vaccination in patients with NHL/CLL. We showed inferior antibody responses against Omicron variants after booster vaccination in these patients but some generated anti-Omicron titers. This stresses the importance of vaccinating patients with updated formulations.

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Hematological Cancers Leukemias Lymphomas Immunology Translational Research

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Supplementary Figure SF4 from Antibody Binding and Neutralization of Live SARS-CoV-2 Variants Including BA.4/5 Following Booster Vaccination of Patients with B-cell Malignancies

Funding

HHS | National Institutes of Health (NIH)

EU | Winship Cancer Institute (Winship Cancer Institute of Emory University)

American Society of Hematology (ASH)

Leukemia and Lymphoma Society (LLS)

EU | School of Medicine, Emory University (Emory University School of Medicine)

History

ARTICLE ABSTRACT

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