Funding
HHS | National Institutes of Health (NIH)
Cancer Research UK (CRUK)
Rosetrees Trust (Rosetrees)
Pelotonia
St. Baldrick's Foundation (SBF)
CancerFree KIDS (CFK)
Steps for Sarcoma
현대자동차그룹 | Hyundai Motor America | Hyundai Hope On Wheels (Hope On Wheels)
ARTICLE ABSTRACT
Chromosomally complex tumors are often described as genomically unstable. However, determining whether complexity arises from remote time-limited events that give rise to structural alterations or a progressive accumulation of structural events in persistently unstable tumors has implications for diagnosis, biomarker assessment, mechanisms of treatment resistance, and represents a conceptual advance in our understanding of intratumoral heterogeneity and tumor evolution.
