American Association for Cancer Research
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Supplementary Figure S8 from Structurally Complex Osteosarcoma Genomes Exhibit Limited Heterogeneity within Individual Tumors and across Evolutionary Time

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journal contribution
posted on 2023-04-12, 14:20 authored by Sanjana Rajan, Simone Zaccaria, Matthew V. Cannon, Maren Cam, Amy C. Gross, Benjamin J. Raphael, Ryan D. Roberts

Bulk data genome SCNA plots by patient

Funding

HHS | National Institutes of Health (NIH)

Cancer Research UK (CRUK)

Rosetrees Trust (Rosetrees)

Pelotonia

St. Baldrick's Foundation (SBF)

CancerFree KIDS (CFK)

Steps for Sarcoma

현대자동차그룹 | Hyundai Motor America | Hyundai Hope On Wheels (Hope On Wheels)

History

ARTICLE ABSTRACT

Chromosomally complex tumors are often described as genomically unstable. However, determining whether complexity arises from remote time-limited events that give rise to structural alterations or a progressive accumulation of structural events in persistently unstable tumors has implications for diagnosis, biomarker assessment, mechanisms of treatment resistance, and represents a conceptual advance in our understanding of intratumoral heterogeneity and tumor evolution.