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Supplementary Figure S7 from Structurally Complex Osteosarcoma Genomes Exhibit Limited Heterogeneity within Individual Tumors and across Evolutionary Time

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posted on 2023-04-12, 14:20 authored by Sanjana Rajan, Simone Zaccaria, Matthew V. Cannon, Maren Cam, Amy C. Gross, Benjamin J. Raphael, Ryan D. Roberts
<p>CHISEL plot for SJOS003939 samples</p>

Funding

HHS | National Institutes of Health (NIH)

Cancer Research UK (CRUK)

Rosetrees Trust (Rosetrees)

Pelotonia

St. Baldrick's Foundation (SBF)

CancerFree KIDS (CFK)

Steps for Sarcoma

현대자동차그룹 | Hyundai Motor America | Hyundai Hope On Wheels (Hope On Wheels)

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    DOI - Is supplement to Structurally Complex Osteosarcoma Genomes Exhibit Limited Heterogeneity within Individual Tumors and across Evolutionary Time

ARTICLE ABSTRACT

Chromosomally complex tumors are often described as genomically unstable. However, determining whether complexity arises from remote time-limited events that give rise to structural alterations or a progressive accumulation of structural events in persistently unstable tumors has implications for diagnosis, biomarker assessment, mechanisms of treatment resistance, and represents a conceptual advance in our understanding of intratumoral heterogeneity and tumor evolution.

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    Cancer Research Communications

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    Keywords

    Genome BiologyStructural genomicsGene TechnologiesComparative genomicsHigh-throughput sequencingSingle Cell TechnologiesPediatric CancersSarcomasOsteosarcoma

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