Supplementary Figure S7 from CD142 Identifies Neoplastic Desmoid Tumor Cells, Uncovering Interactions Between Neoplastic and Stromal Cells That Drive Proliferation

Al-Jazrawe, Mushriq; Xu, Steven; Poon, Raymond; Wei, Qingxia; Przybyl, Joanna; Varma, Sushama; van de Rijn, Matt; Alman, Benjamin A.

doi:10.1158/2767-9764.22692836.v1

crc-22-0403-s07.docx (654.61 kB)

Supplementary Figure S7 from CD142 Identifies Neoplastic Desmoid Tumor Cells, Uncovering Interactions Between Neoplastic and Stromal Cells That Drive Proliferation

journal contribution

posted on 2023-04-25, 14:20 authored by Mushriq Al-Jazrawe, Steven Xu, Raymond Poon, Qingxia Wei, Joanna Przybyl, Sushama Varma, Matt van de Rijn, Benjamin A. Alman

Morphological differences in mutant and non-mutant cells isolated by FACS sorting

Funding

HHS | National Institutes of Health (NIH)

Desmoid Tumor Research Foundation (DTRF)

History

ARTICLE ABSTRACT

Distinguishing between neoplastic (tumor) and non-neoplastic (stromal) cells within mesenchymal tumors is particularly challenging, because lineage-specific cell surface markers typically used in other cancers do not differentiate between the different cell subpopulations. Here, we developed a strategy combining clonal expansion with surface proteome profiling to identify markers for quantifying and isolating mutant and nonmutant cell subpopulations in desmoid tumors, and to study their interactions via soluble factors.

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Rare Cancers Sarcomas Soft-tissue sarcoma Biomarkers Imaging biomarkers Protein biomarkers Cell Signaling Cell-cell interactions Tumor Microenvironment Tumor-stromal cell interactions

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CC BY

Supplementary Figure S7 from CD142 Identifies Neoplastic Desmoid Tumor Cells, Uncovering Interactions Between Neoplastic and Stromal Cells That Drive Proliferation

Funding

HHS | National Institutes of Health (NIH)

Desmoid Tumor Research Foundation (DTRF)

History

ARTICLE ABSTRACT

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