American Association for Cancer Research
Browse
crc-22-0403-s07.docx (654.61 kB)

Supplementary Figure S7 from CD142 Identifies Neoplastic Desmoid Tumor Cells, Uncovering Interactions Between Neoplastic and Stromal Cells That Drive Proliferation

Download (654.61 kB)
journal contribution
posted on 2023-04-25, 14:20 authored by Mushriq Al-Jazrawe, Steven Xu, Raymond Poon, Qingxia Wei, Joanna Przybyl, Sushama Varma, Matt van de Rijn, Benjamin A. Alman

Morphological differences in mutant and non-mutant cells isolated by FACS sorting

Funding

HHS | National Institutes of Health (NIH)

Desmoid Tumor Research Foundation (DTRF)

History

ARTICLE ABSTRACT

Distinguishing between neoplastic (tumor) and non-neoplastic (stromal) cells within mesenchymal tumors is particularly challenging, because lineage-specific cell surface markers typically used in other cancers do not differentiate between the different cell subpopulations. Here, we developed a strategy combining clonal expansion with surface proteome profiling to identify markers for quantifying and isolating mutant and nonmutant cell subpopulations in desmoid tumors, and to study their interactions via soluble factors.

Usage metrics

    Cancer Research Communications

    Categories

    Keywords

    Rare CancersSarcomasSoft-tissue sarcomaBiomarkersImaging biomarkersProtein biomarkersCell SignalingCell-cell interactionsTumor MicroenvironmentTumor-stromal cell interactions

    Licence

    CC BY

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC