American Association for Cancer Research
crc-22-0403-s07.docx (654.61 kB)

Supplementary Figure S7 from CD142 Identifies Neoplastic Desmoid Tumor Cells, Uncovering Interactions Between Neoplastic and Stromal Cells That Drive Proliferation

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journal contribution
posted on 2023-04-25, 14:20 authored by Mushriq Al-Jazrawe, Steven Xu, Raymond Poon, Qingxia Wei, Joanna Przybyl, Sushama Varma, Matt van de Rijn, Benjamin A. Alman

Morphological differences in mutant and non-mutant cells isolated by FACS sorting


HHS | National Institutes of Health (NIH)

Desmoid Tumor Research Foundation (DTRF)



Distinguishing between neoplastic (tumor) and non-neoplastic (stromal) cells within mesenchymal tumors is particularly challenging, because lineage-specific cell surface markers typically used in other cancers do not differentiate between the different cell subpopulations. Here, we developed a strategy combining clonal expansion with surface proteome profiling to identify markers for quantifying and isolating mutant and nonmutant cell subpopulations in desmoid tumors, and to study their interactions via soluble factors.