Supplementary Figure S6 from Mitochondrial Matrix Protease ClpP Agonists Inhibit Cancer Stem Cell Function in Breast Cancer Cells by Disrupting Mitochondrial Homeostasis

Greer, Yoshimi Endo; Hernandez, Lidia; Fennell, Emily M.J.; Kundu, Manjari; Voeller, Donna; Chari, Raj; Gilbert, Samuel F.; Gilbert, Thomas S.K.; Ratnayake, Shashikala; Tang, Binwu; Hafner, Markus; Chen, Qingrong; Meerzaman, Daoud; Iwanowicz, Edwin; Annunziata, Christina M.; Graves, Lee M.; Lipkowitz, Stanley

doi:10.1158/2767-9764.22545596.v1

Supplementary Figure S6 from Mitochondrial Matrix Protease ClpP Agonists Inhibit Cancer Stem Cell Function in Breast Cancer Cells by Disrupting Mitochondrial Homeostasis

journal contribution

posted on 2023-04-04, 01:45 authored by Yoshimi Endo Greer, Lidia Hernandez, Emily M.J. Fennell, Manjari Kundu, Donna Voeller, Raj Chari, Samuel F. Gilbert, Thomas S.K. Gilbert, Shashikala Ratnayake, Binwu Tang, Markus Hafner, Qingrong Chen, Daoud Meerzaman, Edwin Iwanowicz, Christina M. Annunziata, Lee M. Graves, Stanley Lipkowitz

The effects of ClpP agonists and other mitochondria-targeting drugs on mevalonate pathway, YAP/TAZ pathway

Funding

HHS | NIH | National Cancer Institute (NCI)

History

ARTICLE ABSTRACT

ClpP agonists disrupt mitochondrial homeostasis by activating mitochondrial matrix protease ClpP. We report that ClpP agonists inhibit cell growth and CSC functions in breast cancer models by modulating multiple metabolic pathways essential to CSC function.