Supplementary Figure S6 from Caspase-8 Promotes Cell Motility and Calpain Activity under Nonapoptotic Conditions

Helfer, Brooke; Boswell, Bernard C.; Finlay, Darren; Cipres, Angel; Vuori, Kristiina; Bong Kang, Tae; Wallach, David; Dorfleutner, Andrea; Lahti, Jill M.; Flynn, Daniel C.; Frisch, Steven M.

doi:10.1158/0008-5472.22365567.v1

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Supplementary Figure S6 from Caspase-8 Promotes Cell Motility and Calpain Activity under Nonapoptotic Conditions

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posted on 2023-03-30, 17:00 authored by Brooke Helfer, Bernard C. Boswell, Darren Finlay, Angel Cipres, Kristiina Vuori, Tae Bong Kang, David Wallach, Andrea Dorfleutner, Jill M. Lahti, Daniel C. Flynn, Steven M. Frisch

Supplementary Figure S6 from Caspase-8 Promotes Cell Motility and Calpain Activity under Nonapoptotic Conditions

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ARTICLE ABSTRACT

Significant caspase-8 activity has been found in normal and certain tumor cells, suggesting that caspase-8 possesses an alternative, nonapoptotic function that may contribute to tumor progression. In this article, we report that caspase-8 promotes cell motility. In particular, caspase-8 is required for the optimal activation of calpains, Rac, and lamellipodial assembly. This represents a novel nonapoptotic function of caspase-8 acting at the intersection of the caspase-8 and calpain proteolytic pathways to coordinate cell death versus cell motility signaling. (Cancer Res 2006; 66(8): 4273-8)