American Association for Cancer Research

sorry, we can't preview this file

crc-21-0084-s06.docx (646.46 kB)

Supplementary Figure S5 from A Novel PHD2/VHL-mediated Regulation of YAP1 Contributes to VEGF Expression and Angiogenesis

Download (646.46 kB)
journal contribution
posted on 2023-04-04, 01:42 authored by Namrata Bora-Singhal, Biswarup Saha, Durairaj Mohankumar, Jaya Padmanabhan, Domenico Coppola, Srikumar Chellappan

High levels of YAP1-HIF1 alpha levels in mouse tumors


HHS | NIH | Center for Scientific Review (CSR)

Moffitt Cancer Center (MCC)



YAP1 under normoxic conditions is regulated by a novel nonclassical regulatory pathway involving PHD2-mediated prolylhydroxylation and proteasomal degradation; absence of this regulation under hypoxic conditions stabilizes YAP1, contributing to neoangiogenesis.