Supplementary Figure S5 from A Novel PHD2/VHL-mediated Regulation of YAP1 Contributes to VEGF Expression and Angiogenesis

Bora-Singhal, Namrata; Saha, Biswarup; Mohankumar, Durairaj; Padmanabhan, Jaya; Coppola, Domenico; Chellappan, Srikumar

doi:10.1158/2767-9764.22545237.v1

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Supplementary Figure S5 from A Novel PHD2/VHL-mediated Regulation of YAP1 Contributes to VEGF Expression and Angiogenesis

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posted on 2023-04-04, 01:42 authored by Namrata Bora-Singhal, Biswarup Saha, Durairaj Mohankumar, Jaya Padmanabhan, Domenico Coppola, Srikumar Chellappan

High levels of YAP1-HIF1 alpha levels in mouse tumors

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HHS | NIH | Center for Scientific Review (CSR)

Moffitt Cancer Center (MCC)

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ARTICLE ABSTRACT

YAP1 under normoxic conditions is regulated by a novel nonclassical regulatory pathway involving PHD2-mediated prolylhydroxylation and proteasomal degradation; absence of this regulation under hypoxic conditions stabilizes YAP1, contributing to neoangiogenesis.

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Biochemistry Protein/protein interactions Angiogenesis Angiogenic factors and receptors Gene Regulation Mechanisms of transcription Oncogenes & Tumor Suppressors

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Supplementary Figure S5 from A Novel PHD2/VHL-mediated Regulation of YAP1 Contributes to VEGF Expression and Angiogenesis

Funding

HHS | NIH | Center for Scientific Review (CSR)

Moffitt Cancer Center (MCC)

History

ARTICLE ABSTRACT

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Keywords

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