High levels of YAP1-HIF1 alpha levels in mouse tumors
Funding
HHS | NIH | Center for Scientific Review (CSR)
Moffitt Cancer Center (MCC)
History
ARTICLE ABSTRACT
YAP1 under normoxic conditions is regulated by a novel nonclassical regulatory pathway involving PHD2-mediated prolylhydroxylation and proteasomal degradation; absence of this regulation under hypoxic conditions stabilizes YAP1, contributing to neoangiogenesis.