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Supplementary Figure S4 from Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma

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posted on 2025-03-07, 16:00 authored by Megan E. Bischoff, Behrouz Shamsaei, Juechen Yang, Dina Secic, Bhargav Vemuri, Julie A. Reisz, Angelo D’Alessandro, Caterina Bartolacci, Rafal Adamczak, Lucas Schmidt, Jiang Wang, Amelia Martines, Jahnavi Venkat, Vanina Toffessi Tcheuyap, Jacek Biesiada, Catherine A. Behrmann, Katherine E. Vest, James Brugarolas, Pier Paolo Scaglioni, David R. Plas, Krushna C. Patra, Shuchi Gulati, Julio A. Landero Figueroa, Jarek Meller, John T. Cunningham, Maria F. Czyzyk-Krzeska

Glucose metabolism in CuHi and CuLo cells.

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National Cancer Institute (NCI)

United States Department of Health and Human Services

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National Institute of General Medical Sciences (NIGMS)

United States Department of Health and Human Services

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ARTICLE ABSTRACT

The work establishes a requirement for glucose-dependent coordination between energy production and redox homeostasis, which is fundamental for the survival of cancer cells that accumulate Cu and contributes to tumor growth.

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    Cancer Discovery

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    Keywords

    Genitourinary CancersRenal cancerMetabolismMetabolic pathwaysMitochondrial functionProgression, Invasion & MetastasisTumor progressionSingle Cell TechnologiesTumor Evolution

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    CC BY

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