Supplementary Figure S4 from Blocking Tryptophan Catabolism Reduces Triple-Negative Breast Cancer Invasive Capacity

Kuo, Li-Wei; Crump, Lyndsey S.; O’Neill, Kathleen; Williams, Michelle M.; Christenson, Jessica L.; Spoelstra, Nicole S.; Roy, Micaela Kalani; Argabright, Amy; Reisz, Julie A.; D’Alessandro, Angelo; Boorgula, Meher P.; Goodspeed, Andrew; Bickerdike, Mike; Bitler, Benjamin G.; Richer, Jennifer K.

doi:10.1158/2767-9764.27240954

Supplementary Figure S4 from Blocking Tryptophan Catabolism Reduces Triple-Negative Breast Cancer Invasive Capacity

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posted on 2024-10-16, 10:20 authored by Li-Wei Kuo, Lyndsey S. Crump, Kathleen O’Neill, Michelle M. Williams, Jessica L. Christenson, Nicole S. Spoelstra, Micaela Kalani Roy, Amy Argabright, Julie A. Reisz, Angelo D’Alessandro, Meher P. Boorgula, Andrew Goodspeed, Mike Bickerdike, Benjamin G. Bitler, Jennifer K. Richer

<p>Compound AT-0174 decreased secreted KYN in TDO2 overexpression (OE) cells.</p>

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DOI - Is supplement to Blocking Tryptophan Catabolism Reduces Triple-Negative Breast Cancer Invasive Capacity

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TDO2 is more highly expressed than the nonhomologous TRP-catabolizing enzyme IDO1 in TNBC. We find that TDO2 knockdown can lead to a compensatory increase in IDO1. Therefore, we tested a newly developed TDO2/IDO1 dual inhibitor and found that it decreases TRP catabolism, anchorage-independent survival, and invasive capacity.

Supplementary Figure S4 from Blocking Tryptophan Catabolism Reduces Triple-Negative Breast Cancer Invasive Capacity

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