American Association for Cancer Research
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Supplementary Figure S3 from Mitochondrial Matrix Protease ClpP Agonists Inhibit Cancer Stem Cell Function in Breast Cancer Cells by Disrupting Mitochondrial Homeostasis

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posted on 2023-04-04, 01:45 authored by Yoshimi Endo Greer, Lidia Hernandez, Emily M.J. Fennell, Manjari Kundu, Donna Voeller, Raj Chari, Samuel F. Gilbert, Thomas S.K. Gilbert, Shashikala Ratnayake, Binwu Tang, Markus Hafner, Qingrong Chen, Daoud Meerzaman, Edwin Iwanowicz, Christina M. Annunziata, Lee M. Graves, Stanley Lipkowitz

The effect of ClpP agonists on tumor initiation in vivo

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HHS | NIH | National Cancer Institute (NCI)

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ARTICLE ABSTRACT

ClpP agonists disrupt mitochondrial homeostasis by activating mitochondrial matrix protease ClpP. We report that ClpP agonists inhibit cell growth and CSC functions in breast cancer models by modulating multiple metabolic pathways essential to CSC function.

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