Supplementary Figure S3 from Adaptive c-Met-PLXDC2 Signaling Axis Mediates Cancer Stem Cell Plasticity to Confer Radioresistance-associated Aggressiveness in Head and Neck Cancer

Lang, Liwei; Chen, Fanghui; Li, Yamin; Shay, Chloe; Yang, Fan; Dan, Hancai; Chen, Zhuo G.; Saba, Nabil F.; Teng, Yong

doi:10.1158/2767-9764.22657934.v1

crc-22-0289-s04.docx (42.12 kB)

Supplementary Figure S3 from Adaptive c-Met-PLXDC2 Signaling Axis Mediates Cancer Stem Cell Plasticity to Confer Radioresistance-associated Aggressiveness in Head and Neck Cancer

journal contribution

posted on 2023-04-19, 13:20 authored by Liwei Lang, Fanghui Chen, Yamin Li, Chloe Shay, Fan Yang, Hancai Dan, Zhuo G. Chen, Nabil F. Saba, Yong Teng

Inhibitory effect of three c-Met inhibitors on c-Met phosphorylation in CAL27 cells. CAL27 cells were treated with 2.5 µM SU11274, foretinib or crizotinib for 24 hours, followed by Western blotting analysis.

Funding

HHS | NIH | National Institute of Dental and Craniofacial Research (NIDCR)

HHS | NIH | NCI | National Cancer Institute (NCI)

Georgia Clinical and Translational Science Alliance (CTSA)

History

ARTICLE ABSTRACT

This work provides novel insights into c-Met-PLXDC2 signaling in radioresistance-associated aggressiveness and suggests a new mechanism-informed therapeutic strategy to overcome failure of radiotherapy in patients with HNSCC.