Supplementary Figure S3 from Adaptive c-Met-PLXDC2 Signaling Axis Mediates Cancer Stem Cell Plasticity to Confer Radioresistance-associated Aggressiveness in Head and Neck Cancer
posted on 2023-04-19, 13:20authored byLiwei Lang, Fanghui Chen, Yamin Li, Chloe Shay, Fan Yang, Hancai Dan, Zhuo G. Chen, Nabil F. Saba, Yong Teng
Inhibitory effect of three c-Met inhibitors on c-Met phosphorylation in CAL27 cells. CAL27 cells were treated with 2.5 µM SU11274, foretinib or crizotinib for 24 hours, followed by Western blotting analysis.
Funding
HHS | NIH | National Institute of Dental and Craniofacial Research (NIDCR)
HHS | NIH | NCI | National Cancer Institute (NCI)
Georgia Clinical and Translational Science Alliance (CTSA)
History
ARTICLE ABSTRACT
This work provides novel insights into c-Met-PLXDC2 signaling in radioresistance-associated aggressiveness and suggests a new mechanism-informed therapeutic strategy to overcome failure of radiotherapy in patients with HNSCC.