American Association for Cancer Research
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Supplementary Figure S3 from A Model of Intratumor and Interpatient Heterogeneity Explains Clinical Trials of Curative Combination Therapy for Lymphoma

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posted on 2025-05-05, 07:20 authored by Amy E. Pomeroy, Adam C. Palmer

Parameters affect the shape of PFS distributions in unique ways.

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National Cancer Institute (NCI)

United States Department of Health and Human Services

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National Institute of General Medical Sciences (NIGMS)

United States Department of Health and Human Services

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ARTICLE ABSTRACT

A new model of intratumor and interpatient heterogeneity in response to drug combinations explains and predicts the results of clinical trials of curative-intent treatments for DLBCL. This model can be used to understand and inform optimal design of curative drug combinations and clinical trials.See related commentary by Goldstein et al., p. 153

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    Blood Cancer Discovery

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    Keywords

    ChemotherapyCombination chemotherapyComputational MethodsMathematical modelingHematological CancersLymphomasSystems BiologyTumor Heterogeneity

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