American Association for Cancer Research
crc-23-0102-s04.pdf (14.29 MB)

Supplementary Figure S2 from Sequential Chromogenic IHC: Spatial Analysis of Lymph Nodes Identifies Contact Interactions between Plasmacytoid Dendritic Cells and Plasmablasts

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journal contribution
posted on 2023-07-21, 17:40 authored by Natalie Claudio, My-Tien Nguyen, Adrian Wanner, Ferdinando Pucci

Alignment results. Comparison of before and after alignment for CD3 (red, top) and CD20 (red, bottom) superimposed with hematoxylin (green).


V Foundation for Cancer Research (VFCR)

Cancer Research UK (CRUK)



We present a comprehensive guide for developing customized biomarker panels to investigate cell–cell interactions in the context of immune responses in cancer. This approach revealed novel contact interactions between plasmablasts and plasmacytoid dendritic cells in lymph nodes from patients with head and neck cancer.