Supplementary Figure S1 from Whole-genome and Epigenomic Landscapes of Malignant Gastrointestinal Stromal Tumors Harboring KIT Exon 11 557–558 Deletion Mutations

Ohshima, Keiichi; Nagashima, Takeshi; Fujiya, Keiichi; Hatakeyama, Keiichi; Watanabe, Yuko; Morimoto, Kimiko; Kamada, Fukumi; Shimoda, Yuji; Ohnami, Sumiko; Naruoka, Akane; Serizawa, Masakuni; Ohnami, Shumpei; Kenmotsu, Hirotsugu; Shiomi, Akio; Tsubosa, Yasuhiro; Bando, Etsuro; Sugiura, Teiichi; Sugino, Takashi; Terashima, Masanori; Uesaka, Katsuhiko; Urakami, Kenichi; Akiyama, Yasuto; Yamaguchi, Ken

doi:10.1158/2767-9764.22684228.v1

crc-22-0364-s01.docx (13.18 MB)

Supplementary Figure S1 from Whole-genome and Epigenomic Landscapes of Malignant Gastrointestinal Stromal Tumors Harboring KIT Exon 11 557–558 Deletion Mutations

journal contribution

posted on 2023-04-24, 14:20 authored by Keiichi Ohshima, Takeshi Nagashima, Keiichi Fujiya, Keiichi Hatakeyama, Yuko Watanabe, Kimiko Morimoto, Fukumi Kamada, Yuji Shimoda, Sumiko Ohnami, Akane Naruoka, Masakuni Serizawa, Shumpei Ohnami, Hirotsugu Kenmotsu, Akio Shiomi, Yasuhiro Tsubosa, Etsuro Bando, Teiichi Sugiura, Takashi Sugino, Masanori Terashima, Katsuhiko Uesaka, Kenichi Urakami, Yasuto Akiyama, Ken Yamaguchi

Circos plots of the 30 GIST genomes in our study cohort.

Funding

Shizuoka Cancer Center (SCC)

History

ARTICLE ABSTRACT

We present genomic and epigenomic insights into the malignant progression of GISTs with KIT exon 11 deletions involving in 557–558, demonstrating their unique chromosomal instability and global intergenic DNA hypomethylation.