Supplementary Figure S1 from Blocking Tryptophan Catabolism Reduces Triple-Negative Breast Cancer Invasive Capacity

Kuo, Li-Wei; Crump, Lyndsey S.; O’Neill, Kathleen; Williams, Michelle M.; Christenson, Jessica L.; Spoelstra, Nicole S.; Roy, Micaela Kalani; Argabright, Amy; Reisz, Julie A.; D’Alessandro, Angelo; Boorgula, Meher P.; Goodspeed, Andrew; Bickerdike, Mike; Bitler, Benjamin G.; Richer, Jennifer K.

doi:10.1158/2767-9764.27248975

Supplementary Figure S1 from Blocking Tryptophan Catabolism Reduces Triple-Negative Breast Cancer Invasive Capacity

journal contribution

posted on 2024-10-17, 13:40 authored by Li-Wei Kuo, Lyndsey S. Crump, Kathleen O’Neill, Michelle M. Williams, Jessica L. Christenson, Nicole S. Spoelstra, Micaela Kalani Roy, Amy Argabright, Julie A. Reisz, Angelo D’Alessandro, Meher P. Boorgula, Andrew Goodspeed, Mike Bickerdike, Benjamin G. Bitler, Jennifer K. Richer

Gene enrichment set analysis (GSEA) for MDA-MB-453 forced suspension culture vs. attached culture.

History

ARTICLE ABSTRACT

TDO2 is more highly expressed than the nonhomologous TRP-catabolizing enzyme IDO1 in TNBC. We find that TDO2 knockdown can lead to a compensatory increase in IDO1. Therefore, we tested a newly developed TDO2/IDO1 dual inhibitor and found that it decreases TRP catabolism, anchorage-independent survival, and invasive capacity.