American Association for Cancer Research
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Supplementary Figure S1 from A Novel PHD2/VHL-mediated Regulation of YAP1 Contributes to VEGF Expression and Angiogenesis

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journal contribution
posted on 2023-04-04, 01:42 authored by Namrata Bora-Singhal, Biswarup Saha, Durairaj Mohankumar, Jaya Padmanabhan, Domenico Coppola, Srikumar Chellappan

Transient transfection data

Funding

HHS | NIH | Center for Scientific Review (CSR)

Moffitt Cancer Center (MCC)

History

ARTICLE ABSTRACT

YAP1 under normoxic conditions is regulated by a novel nonclassical regulatory pathway involving PHD2-mediated prolylhydroxylation and proteasomal degradation; absence of this regulation under hypoxic conditions stabilizes YAP1, contributing to neoangiogenesis.