Supplementary Figure S1 - Figure S7Data from β8 Integrin Mediates Pancreatic Cancer Cell Radiochemoresistance

<p>Supplementary Figure 1. Flowchart of high throughout screen (3D HTesiRNAS) in 3D PDAC organoids. Supplementary Figure 2. β8 integrin expression in cell fractions. Supplementary Figure 3. β8 integrin knockdown also radiosensitizes 2D PDAC cell cultures. Supplementary Figure 4. Co-immunofluorescence staining of β8 integrin with GM130, mitotracker, αV integrin, APPL2 and Caveolin. Supplementary Figure 5. Impact of αV integrin expression on survival of patients with PDAC. Supplementary Figure 6. Cytotoxicity of Gemcitabine, chloroquine, colchicine and paclitaxel in BxPC cells. Supplementary Figure 7. β8 integrin and LC3B double staining upon β8 integrin knockdown. Supplementary Table 1. Data of high-throughput esiRNA knockdown screen of 117 focal adhesion proteins in 3D PDAC cell culture. RLUC was the control. Supplementary Table 2. Classification of proteins of the β8 integrin interactome based on raw data of sequential immunoprecipitation-mass spectrometry using PANTHER database</p>