American Association for Cancer Research
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Supplementary Figure S13 from Tumor Cell–Autonomous SHP2 Contributes to Immune Suppression in Metastatic Breast Cancer

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journal contribution
posted on 2023-04-04, 01:41 authored by Hao Chen, Gregory M. Cresswell, Sarah Libring, Mitchell G. Ayers, Jinmin Miao, Zhong-Yin Zhang, Luis Solorio, Timothy L. Ratliff, Michael K. Wendt

Inhibition or depletion of SHP2 and PD-L1 blockade rescue T cell cytotoxicity.

Funding

HHS | NIH | National Cancer Institute (NCI)

Indiana Clinical and Translational Science Institute

American Cancer Society (ACS)

History

ARTICLE ABSTRACT

Findings present inhibition of SHP2 as a therapeutic option to limit breast cancer metastasis by promoting antitumor immunity.