Supplementary Figure S13 from Tumor Cell–Autonomous SHP2 Contributes to Immune Suppression in Metastatic Breast Cancer

Chen, Hao; Cresswell, Gregory M.; Libring, Sarah; Ayers, Mitchell G.; Miao, Jinmin; Zhang, Zhong-Yin; Solorio, Luis; Ratliff, Timothy L.; Wendt, Michael K.

doi:10.1158/2767-9764.22545150.v1

Supplementary Figure S13 from Tumor Cell–Autonomous SHP2 Contributes to Immune Suppression in Metastatic Breast Cancer

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posted on 2023-04-04, 01:41 authored by Hao Chen, Gregory M. Cresswell, Sarah Libring, Mitchell G. Ayers, Jinmin Miao, Zhong-Yin Zhang, Luis Solorio, Timothy L. Ratliff, Michael K. Wendt

Inhibition or depletion of SHP2 and PD-L1 blockade rescue T cell cytotoxicity.

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HHS | NIH | National Cancer Institute (NCI)

Indiana Clinical and Translational Science Institute

American Cancer Society (ACS)

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ARTICLE ABSTRACT

Findings present inhibition of SHP2 as a therapeutic option to limit breast cancer metastasis by promoting antitumor immunity.

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Preclinical Models Animal models of cancer Breast Cancer Tumor Microenvironment Immune cells and the microenvironment Immunology Immunomodulation T cell exhaustion Immunotherapy Antibody immunotherapy Cell Signaling Phosphatases

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Supplementary Figure S13 from Tumor Cell–Autonomous SHP2 Contributes to Immune Suppression in Metastatic Breast Cancer

Funding

HHS | NIH | National Cancer Institute (NCI)

Indiana Clinical and Translational Science Institute

American Cancer Society (ACS)

History

ARTICLE ABSTRACT

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Keywords

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