Supplementary Figure Legends from WWOX Inhibits Metastasis of Triple-Negative Breast Cancer Cells via Modulation of miRNAs

Supplementary Figure 1: Relapse-free survival (RFS) analysis for WWOX in KM plotter. Supplementary Figure 2: Relapse-free survival (RFS) analysis for the WWOX gene in TCGA dataset. Supplementary Figure 3: Boxplots for each comparison of the expression of the specific gene between WWOX+ (>75th percentile) and WWOX- (<25th percentile) samples. Supplementary Figure 4: WWOX restoration reduces proliferation and Matrigel invasion in vitro. Supplementary Figure 5: WWOX restoration attenuates mammary tumor growth and inhibits metastasis formation in vivo. Supplementary Figure 6: WWOX restoration inhibits metastasis formation and colonization in vivo. Supplementary figure 7: Effect of WWOX manipulation in TNBC cells. Supplementary figure 8: WWOX negatively regulates Fibronectin expression in vivo. Supplementary figure 9: WWOX overexpression modulates microRNAs expression. Supplementary figure 10: Inverse correlation between Fibronectin and miR-146a in TNBC samples. Supplementary Figure 11: miR-146a expression predicts improved survival in triple-negative breast cancer patients. Supplementary Figure 12: WWOX overexpression inhibits MYC activity. Supplementary figure 13: Densitometric quantification of all western blots.