Supplementary Figure Legends from New Blocking Antibodies against Novel AGR2–C4.4A Pathway Reduce Growth and Metastasis of Pancreatic Tumors and Increase Survival in Mice
posted on 2023-04-03, 14:11authored byThiruvengadam Arumugam, Defeng Deng, Laura Bover, Huamin Wang, Craig D. Logsdon, Vijaya Ramachandran
Extracellular rAGR2-mediated functions, Candidate receptors binding and silencing, Silencing C4.4A reduced basal and rAGR2-mediated functions, Effects of AGR2 are mediated by C4.4A interacting with integrin beta 1, Monoclonal antibodies developed bind respectively to AGR2 and C4.4A proteins and blocked their functions, In Vivo treatment with AGR2/C4.4A antibodies reduced tumor volume are described as the experiment is conducted.