Supplementary Figure FS2 from Comprehensive Characterization of the Multiple Myeloma Immune Microenvironment Using Integrated scRNA-seq, CyTOF, and CITE-seq Analysis

Yao, Lijun; Jayasinghe, Reyka G.; Lee, Brian H.; Bhasin, Swati S.; Pilcher, William; Doxie, Deon Bryant; Gonzalez-Kozlova, Edgar; Dasari, Surendra; Fiala, Mark A.; Pita-Juarez, Yered; Strausbauch, Michael; Kelly, Geoffrey; Thomas, Beena E.; Kumar, Shaji K.; Cho, Hearn Jay; Anderson, Emilie; Wendl, Michael C.; Dawson, Travis; D'souza, Darwin; Oh, Stephen T.; Cheloni, Giulia; Li, Ying; DiPersio, John F.; Rahman, Adeeb H.; Dhodapkar, Kavita M.; Kim-Schulze, Seunghee; Vij, Ravi; Vlachos, Ioannis S.; Mehr, Shaadi; Hamilton, Mark; Auclair, Daniel; Kourelis, Taxiarchis; Avigan, David; Dhodapkar, Madhav V.; Gnjatic, Sacha; Bhasin, Manoj K.; Ding, Li

doi:10.1158/2767-9764.22545044.v1

Supplementary Figure FS2 from Comprehensive Characterization of the Multiple Myeloma Immune Microenvironment Using Integrated scRNA-seq, CyTOF, and CITE-seq Analysis

journal contribution

posted on 2023-04-04, 01:41 authored by Lijun Yao, Reyka G. Jayasinghe, Brian H. Lee, Swati S. Bhasin, William Pilcher, Deon Bryant Doxie, Edgar Gonzalez-Kozlova, Surendra Dasari, Mark A. Fiala, Yered Pita-Juarez, Michael Strausbauch, Geoffrey Kelly, Beena E. Thomas, Shaji K. Kumar, Hearn Jay Cho, Emilie Anderson, Michael C. Wendl, Travis Dawson, Darwin D'souza, Stephen T. Oh, Giulia Cheloni, Ying Li, John F. DiPersio, Adeeb H. Rahman, Kavita M. Dhodapkar, Seunghee Kim-Schulze, Ravi Vij, Ioannis S. Vlachos, Shaadi Mehr, Mark Hamilton, Daniel Auclair, Taxiarchis Kourelis, David Avigan, Madhav V. Dhodapkar, Sacha Gnjatic, Manoj K. Bhasin, Li Ding

Correlation of expression of canonical cell type markers across different modalities

Funding

Multiple Myeloma Research Foundation (MMRF)

History

ARTICLE ABSTRACT

scRNA-seq, CyTOF, and CITE-seq are increasingly used for evaluating cellular heterogeneity. Understanding their concordances is of great interest. To date, this study is the most comprehensive examination of the measurement of the immune microenvironment in multiple myeloma using the three techniques. Moreover, we identified markers predicted to be significantly associated with multiple myeloma rapid progression.