American Association for Cancer Research
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Supplementary Figure 8 from Targeted Single-cell Isolation of Spontaneously Escaping Live Melanoma Cells for Comparative Transcriptomics

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posted on 2023-08-11, 14:20 authored by Jacqueline L.E. Tearle, Satya N.V. Arjunan, Szun S. Tay, Feyza Colakoglu, James Cremasco, Matteo Golo, Maté Biro

Supplementary Figure 8 shows a summary of GSEA pathway analyses using Hallmarks gene set showing top 25 enriched pathways for each comparison

Funding

EMBL Australia (EMBL-Australia)

Cancer Institute NSW (Cancer Institute New South Wales)

Cure Cancer Australia Foundation (CCAF)

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ARTICLE ABSTRACT

This work describes a readily implementable method that allows for the isolation of individual live tumor cells of interest for downstream analyses, and provides the single-cell transcriptomes of melanoma cells at distinct invasive states, both of which open avenues for in-depth investigations into the transcriptional regulation of the earliest phases of metastasis.

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    Cancer Research Communications

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    Keywords

    Progression, Invasion & MetastasisMigration and invasionImaging of tumor progression and metastasisMetastasisSkin CancersMelanomaSingle Cell TechnologiesImagingGenome BiologyComparative transcriptomics

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    CC BY

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