American Association for Cancer Research
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Supplementary Figure 8 from A Tumorigenic MLL-Homeobox Network in Human Glioblastoma Stem Cells

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journal contribution
posted on 2023-03-30, 21:51 authored by Marco Gallo, Jenny Ho, Fiona J. Coutinho, Robert Vanner, Lilian Lee, Renee Head, Erick K. M. Ling, Ian D. Clarke, Peter B. Dirks

PDF file - 540K, Injections of different cell doses for G411NS and GliNS1 cells in mice



Glioblastoma growth is driven by cancer cells that have stem cell properties, but molecular determinants of their tumorigenic behavior are poorly defined. In cancer, altered activity of the epigenetic modifiers Polycomb and Trithorax complexes may contribute to the neoplastic phenotype. Here, we provide the first mechanistic insights into the role of the Trithorax protein mixed lineage leukemia (MLL) in maintaining cancer stem cell characteristics in human glioblastoma. We found that MLL directly activates the Homeobox gene HOXA10. In turn, HOXA10 activates a downstream Homeobox network and other genes previously characterized for their role in tumorigenesis. The MLL–Homeobox axis we identified significantly contributes to the tumorigenic potential of glioblastoma stem cells. Our studies suggest a role for MLL in contributing to the epigenetic heterogeneity between tumor-initiating and non–tumor-initiating cells in glioblastoma. Cancer Res; 73(1); 417–27. ©2012 AACR.

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