Supplementary Figure 7 from Threonine 2609 Phosphorylation of the DNA-Dependent Protein Kinase Is a Critical Prerequisite for Epidermal Growth Factor Receptor–Mediated Radiation Resistance
posted on 2023-04-03, 17:40authored byPrashanthi Javvadi, Haruhiko Makino, Amit K. Das, Yu-Fen Lin, David J. Chen, Benjamin P. Chen, Chaitanya S. Nirodi
PDF file - 774K, Proximity ligation assay (PLA): To detect radiation-induced PP2A-DNA-PKcs binding. NSCLCs and HBEC cells expressing WT or gammaE746-E750 EGFR fixed 1 h following 0 Gy or 4 Gy IR. Left panel: representative images of nuclei (blue) and EGFR-DNA-PKcs complexes (red: PLA fluorescence). Square boxes represent cropped images shown in Figure 7C