Supplementary Figure 7 from Aptamer:Toxin Conjugates that Specifically Target Prostate Tumor Cells

Chu, Ted C.; Marks, John W.; Lavery, Laura A.; Faulkner, Sarah; Rosenblum, Michael G.; Ellington, Andrew D.; Levy, Matthew

doi:10.1158/0008-5472.22365435.v1

Supplementary Figure 7 from Aptamer:Toxin Conjugates that Specifically Target Prostate Tumor Cells

https://doi.org/10.1158/0008-5472.22365435

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posted on 2023-03-30, 16:49 authored by Ted C. Chu, John W. Marks, Laura A. Lavery, Sarah Faulkner, Michael G. Rosenblum, Andrew D. Ellington, Matthew Levy

Supplementary Figure 7 from Aptamer:Toxin Conjugates that Specifically Target Prostate Tumor Cells

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DOI - Is supplement to Aptamer:Toxin Conjugates that Specifically Target Prostate Tumor Cells

ARTICLE ABSTRACT

We have used RNA aptamer:gelonin conjugates to target and specifically destroy cells overexpressing the known cancer biomarker prostate-specific membrane antigen (PSMA). Aptamer:toxin conjugates have an IC50 of 27 nmol/L and display an increased potency of at least 600-fold relative to cells that do not express PSMA. The aptamer not only promotes uptake into target cells but also decreases the toxicity of gelonin in non-target cells. These results validate the notion that “escort aptamers” may be useful for the treatment of specific tumors expressing unique antigen targets.(Cancer Res 2006; 66(12): 5989-92)

Supplementary Figure 7 from Aptamer:Toxin Conjugates that Specifically Target Prostate Tumor Cells

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