journal contribution
posted on 2023-04-04, 01:44 authored by Mariana Cooke, Xuyao Zhang, Suli Zhang, Evgeniy Eruslanov, Priti Lal, Reba E. Daniel, Michael D. Feldman, Martin C. Abba, Marcelo G. Kazanietz Reduced production of cytokines in PC3 cells subjected to PKCalpha RNAi depletion. IL-8 and GRO were measured in conditioned medium of PC3 cells by ELISA.
Funding
HHS | NIH | National Cancer Institute (NCI)
Agencia Nacional de Promoción de la Investigación, el Desarrollo Tecnológico y la Innovación (National Agency for the Promotion of Research, Technological Development and Innovation)
History
ARTICLE ABSTRACT
PKCα was found to be aberrantly expressed in human prostate cancer. Silencing the expression of this kinase from aggressive prostate cancer cell lines reduces their proliferative, tumorigenic, and invasive properties. In addition, our findings implicate PKCα as a major node for transcriptional regulation of tumorigenic, inflammatory, and EMT networks in prostate cancer, highlighting its potential relevance as a therapeutic target.
