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Supplementary Figure 5 from ZBRK1 Acts as a Metastatic Suppressor by Directly Regulating MMP9 in Cervical Cancer

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posted on 2023-03-30, 19:27 authored by Li-Fang Lin, Chih-Hung Chuang, Chien-Feng Li, Ching-Chun Liao, Chun-Pei Cheng, Tian-Lu Cheng, Meng-Ru Shen, Joseph T. Tseng, Wen-Chang Chang, Wen-Hwa Lee, Ju-Ming Wang
Supplementary Figure 5 from ZBRK1 Acts as a Metastatic Suppressor by Directly Regulating MMP9 in Cervical Cancer

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ARTICLE ABSTRACT

The BRCA1-interacted transcriptional repressor ZBRK1 has been associated with antiangiogenesis, but direct evidence of a tumor suppressor role has been lacking. In this study, we provide evidence of such a role in cervical carcinoma. ZBRK1 levels in cervical tumor cells were significantly lower than in normal cervical epithelial cells. In HeLa cervical cancer cells, enforced expression inhibited malignant growth, invasion, and metastasis in a variety of in vitro and in vivo assays. Expression of the metalloproteinase MMP9, which is known to be an important driver of invasion and metastasis, was found to be inversely correlated with ZBRK1 in tumor tissues and a target for repression in tumor cells. Our findings suggest that ZBRK1 acts to inhibit metastasis of cervical carcinoma, perhaps by modulating MMP9 expression. Cancer Res; 70(1); 192–201

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    Cancer Research

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    BiomarkersComputational MethodsGene expression profilingGene RegulationMechanisms of transcriptionGynecological CancersCervical cancerOncogenes & Tumor SuppressorsSuppressors of metastasisProgression, Invasion & MetastasisCell adhesion and extracellular matrixMetastasisMigration and invasion

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