Supplementary Figure 4 from β2-Microglobulin Induces Epithelial to Mesenchymal Transition and Confers Cancer Lethality and Bone Metastasis in Human Cancer Cells

Josson, Sajni; Nomura, Takeo; Lin, Jen-Tai; Huang, Wen-Chin; Wu, Daqing; Zhau, Haiyen E.; Zayzafoon, Majd; Weizmann, M. Neale; Gururajan, Murali; Chung, Leland W. K.

doi:10.1158/0008-5472.22390001.v1

Supplementary Figure 4 from β2-Microglobulin Induces Epithelial to Mesenchymal Transition and Confers Cancer Lethality and Bone Metastasis in Human Cancer Cells

journal contribution

posted on 2023-03-30, 20:44 authored by Sajni Josson, Takeo Nomura, Jen-Tai Lin, Wen-Chin Huang, Daqing Wu, Haiyen E. Zhau, Majd Zayzafoon, M. Neale Weizmann, Murali Gururajan, Leland W. K. Chung

Supplementary Figure 4 from β2-Microglobulin Induces Epithelial to Mesenchymal Transition and Confers Cancer Lethality and Bone Metastasis in Human Cancer Cells

History

ARTICLE ABSTRACT

Bone metastasis is one of the predominant causes of cancer lethality. This study demonstrates for the first time how β2-microglobulin (β2-M) supports lethal metastasis in vivo in human prostate, breast, lung, and renal cancer cells. β2-M mediates this process by activating epithelial to mesenchymal transition (EMT) to promote lethal bone and soft tissue metastases in host mice. β2-M interacts with its receptor, hemochromatosis (HFE) protein, to modulate iron responsive pathways in cancer cells. Inhibition of either β2-M or HFE results in reversion of EMT. These results demonstrate the role of β2-M in cancer metastasis and lethality. Thus, β2-M and its downstream signaling pathways are promising prognostic markers of cancer metastases and novel therapeutic targets for cancer therapy. Cancer Res; 71(7); 2600–10. ©2011 AACR.