Supplementary Figure 3 from Tumor Purity in Preclinical Mouse Tumor Models

Qian, Wubin; Chen, Xiaobo; Sheng, Yanghui; Zhang, Likun; Wang, Jingjing; Song, Zhenzhen; Li, Qi-Xiang; Guo, Sheng

doi:10.1158/2767-9764.22544370.v1

crc-21-0126-s04.pdf (362.72 kB)

Supplementary Figure 3 from Tumor Purity in Preclinical Mouse Tumor Models

journal contribution

posted on 2023-04-04, 01:22 authored by Wubin Qian, Xiaobo Chen, Yanghui Sheng, Likun Zhang, Jingjing Wang, Zhenzhen Song, Qi-Xiang Li, Sheng Guo

Median variant allelic fraction (VAF) of missense mutations in cancer cell lines and patient tumors.

History

ARTICLE ABSTRACT

PDX models are an ideal experimental system to study tumor purity because of its distinct separation of human tumor cells and mouse stromal and immune cells. This study provides a comprehensive view of tumor purity in 27 cancers in PDX models. It also investigates tumor purity in 19 syngeneic models based on unambiguously identified somatic mutations. It will facilitate tumor microenvironment research and drug development in mouse tumor models.