Supplementary Figure 3 from Kinase Inhibitor Pulldown Assay Identifies a Chemotherapy Response Signature in Triple-negative Breast Cancer Based on Purine-binding Proteins

Wang, Junkai; Saltzman, Alexander B.; Jaehnig, Eric J.; Lei, Jonathan T.; Malovannaya, Anna; Holt, Matthew V.; Young, Meggie N.; Rimawi, Mothaffar F.; Ademuyiwa, Foluso O.; Anurag, Meenakshi; Kim, Beom-Jun; Ellis, Matthew J.

doi:10.1158/2767-9764.23958035.v1

crc-22-0501-s04.pdf (2.18 MB)

Supplementary Figure 3 from Kinase Inhibitor Pulldown Assay Identifies a Chemotherapy Response Signature in Triple-negative Breast Cancer Based on Purine-binding Proteins

journal contribution

posted on 2023-08-15, 14:20 authored by Junkai Wang, Alexander B. Saltzman, Eric J. Jaehnig, Jonathan T. Lei, Anna Malovannaya, Matthew V. Holt, Meggie N. Young, Mothaffar F. Rimawi, Foluso O. Ademuyiwa, Meenakshi Anurag, Beom-Jun Kim, Matthew J. Ellis

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Funding

HHS | NIH | National Cancer Institute (NCI)

Cancer Prevention and Research Institute of Texas (CPRIT)

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ARTICLE ABSTRACT

The identification of pretreatment predictive biomarkers for pCR in response to neoadjuvant chemotherapy would advance precision treatment for TNBC. To complement standard proteogenomic discovery profiling, a KIPA was deployed and unexpectedly identified a seven-member non-kinase PBP pCR-associated signature. Individual members served diverse pathways including IFN gamma response, nuclear import of DNA repair proteins, and cell death.

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Breast Cancer Biomarkers Protein biomarkers Prognostic biomarkers Chemotherapy Proteomics Small Molecule Agents Kinase inhibitors

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Supplementary Figure 3 from Kinase Inhibitor Pulldown Assay Identifies a Chemotherapy Response Signature in Triple-negative Breast Cancer Based on Purine-binding Proteins

Funding

HHS | NIH | National Cancer Institute (NCI)

Cancer Prevention and Research Institute of Texas (CPRIT)

History

ARTICLE ABSTRACT

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