Supplementary Figure 2 from The Transcriptional Repressor ZEB1 Promotes Metastasis and Loss of Cell Polarity in Cancer

Spaderna, Simone; Schmalhofer, Otto; Wahlbuhl, Mandy; Dimmler, Arno; Bauer, Katja; Sultan, Aneesa; Hlubek, Falk; Jung, Andreas; Strand, Dennis; Eger, Andreas; Kirchner, Thomas; Behrens, Jürgen; Brabletz, Thomas

doi:10.1158/0008-5472.22374971.v1

Supplementary Figure 2 from The Transcriptional Repressor ZEB1 Promotes Metastasis and Loss of Cell Polarity in Cancer

journal contribution

posted on 2023-03-30, 18:12 authored by Simone Spaderna, Otto Schmalhofer, Mandy Wahlbuhl, Arno Dimmler, Katja Bauer, Aneesa Sultan, Falk Hlubek, Andreas Jung, Dennis Strand, Andreas Eger, Thomas Kirchner, Jürgen Behrens, Thomas Brabletz

Supplementary Figure 2 from The Transcriptional Repressor ZEB1 Promotes Metastasis and Loss of Cell Polarity in Cancer

History

ARTICLE ABSTRACT

Invasion and metastasis are the hallmarks of malignant tumor progression and the main cause of death in cancer. The embryonic program “epithelial-mesenchymal transition” (EMT) is thought to trigger invasion by allowing tumor cell dissemination. Here, we describe that the EMT-inducing transcriptional repressor ZEB1 promotes colorectal cancer cell metastasis and loss of cell polarity. Thereby, ZEB1 suppresses the expression of cell polarity factors, in particular of Lgl2, which we found reduced in colorectal and breast cancers. We further show that retention of Lgl2 expression is critical for the epithelial phenotype and that its loss might be involved in metastasis. Thus, by linking EMT, loss of polarity, and metastasis, ZEB1 is a crucial promoter of malignant tumor progression. [Cancer Res 2008;68(2):537–44]