American Association for Cancer Research
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Supplementary Figure 2 from Endothelial VEGFR Coreceptors Neuropilin-1 and Neuropilin-2 Are Essential for Tumor Angiogenesis

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journal contribution
posted on 2023-04-04, 02:02 authored by Christopher J. Benwell, Robert T. Johnson, James A.G.E. Taylor, Christopher A. Price, Stephen D. Robinson

Angiogenesis is inhibited in PyMT-BO1 tumours upon NRP1 and NRP2 depletion

Funding

UKRI | Biotechnology and Biological Sciences Research Council (BBSRC)

British Heart Foundation (BHF)

BigC Cancer Charity

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ARTICLE ABSTRACT

The findings presented in this study demonstrate that tumor angiogenesis and growth can be arrested completely by cotargeting endothelial NRP1 and NRP2. We provide new insight into the mechanisms of action regulating NRP-dependent tumor angiogenesis and signpost a novel approach to halt tumor progression.

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    Cancer Research Communications

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    Keywords

    AngiogenesisAngiogenesis mechanismsAngiogenesis inhibitors & stimulatorsProgression, Invasion & MetastasisCell adhesion and extracellular matrix

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