posted on 2023-04-04, 02:02authored byChristopher J. Benwell, Robert T. Johnson, James A.G.E. Taylor, Christopher A. Price, Stephen D. Robinson
Angiogenesis is inhibited in PyMT-BO1 tumours upon NRP1 and NRP2 depletion
Funding
UKRI | Biotechnology and Biological Sciences Research Council (BBSRC)
British Heart Foundation (BHF)
BigC Cancer Charity
History
ARTICLE ABSTRACT
The findings presented in this study demonstrate that tumor angiogenesis and growth can be arrested completely by cotargeting endothelial NRP1 and NRP2. We provide new insight into the mechanisms of action regulating NRP-dependent tumor angiogenesis and signpost a novel approach to halt tumor progression.