posted on 2023-03-31, 17:22authored byKadoaki Ohashi, Lecia V. Sequist, Maria E. Arcila, Christine M. Lovly, Xi Chen, Charles M. Rudin, Teresa Moran, David Ross Camidge, Cindy L. Vnencak-Jones, Lynne Berry, Yumei Pan, Hidefumi Sasaki, Jeffrey A. Engelman, Edward B. Garon, Steven M. Dubinett, Wilbur A. Franklin, Gregory J. Riely, Martin L. Sos, Mark G. Kris, Dora Dias-Santagata, Marc Ladanyi, Paul A. Bunn, William Pao
PDF file - 70K, Figure S2. Effect of a MEK inhibitor against HCC15 cells in combination with either a MET or IGF-1R inhibitor. A. The combination of SGX-523 and trametinib did not inhibit cell growth in HCC15 cells. B. The combination of linsitiniband trametinib showed a greater effect than either drug alone. We used linsitinib because we previously reported that HCC15 cells harbor high levels of IGF-1R (36).