American Association for Cancer Research
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mcr-22-0843_supplementary_figure_1_suppsf1.pdf (2.31 MB)

Supplementary Figure 1 from Non-Essential Amino Acid Availability Influences Proteostasis and Breast Cancer Cell Survival During Proteotoxic Stress

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posted on 2023-04-19, 14:00 authored by Sara Sannino, Allison M. Manuel, Chaowei Shang, Stacy G. Wendell, Peter Wipf, Jeffrey L. Brodsky

S1. Amino acid modulation orchestrates apoptosis when proteostasis is compromised.

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ARTICLE ABSTRACT

These data position amino acid abundance, GCN2, mTORC1, and autophagy as integrated therapeutic targets whose coordinated modulation regulates the survival of proteotoxic-resistant breast cancer cells.

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    Molecular Cancer Research

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    cancer

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