Supplementary Figure 1 from A CD90+ Tumor-Initiating Cell Population with an Aggressive Signature and Metastatic Capacity in Esophageal Cancer

Tang, Kwan Ho; Dai, Yong Dong; Tong, Man; Chan, Yuen Piu; Kwan, Pak Shing; Fu, Li; Qin, Yan Ru; Tsao, Sai Wah; Lung, Hong Lok; Lung, Maria L.; Tong, Daniel K.; Law, Simon; Chan, Kwok Wah; Ma, Stephanie; Guan, Xin Yuan

doi:10.1158/0008-5472.22398549.v1

00085472can122991-sup-fig1.pdf (490.13 kB)

Supplementary Figure 1 from A CD90⁺ Tumor-Initiating Cell Population with an Aggressive Signature and Metastatic Capacity in Esophageal Cancer

journal contribution

posted on 2023-03-30, 22:01 authored by Kwan Ho Tang, Yong Dong Dai, Man Tong, Yuen Piu Chan, Pak Shing Kwan, Li Fu, Yan Ru Qin, Sai Wah Tsao, Hong Lok Lung, Maria L. Lung, Daniel K. Tong, Simon Law, Kwok Wah Chan, Stephanie Ma, Xin Yuan Guan

PDF file - 490K, Supplemental Figure 1. A significantly deregulated network of genes in CD90+ esophageal T-ICs identified by genome-wide expression profiling and Ingenuity Pathway Analysis (IPA).

History

ARTICLE ABSTRACT

Tumor-initiating cells (TIC), also known as cancer stem cells, are regarded widely as a specific subpopulation of cells needed for cancer initiation and progression. TICs have yet to be identified in esophageal tumors that have an increasing incidence in developed countries. Here, we report a CD90+ cell population found in esophageal squamous cell carcinoma (ESCC), which is endowed with stem cell–like properties and high tumorigenic and metastatic potential. mRNA profiling of these cells suggested pathways through which they drive tumor growth and metastasis, with deregulation of an Ets-1/MMP signaling pathway and epithelial–mesenchymal transition figuring prominently. These cells possessed higher self-renewal activity and were sufficient for tumor growth, differentiation, metastasis, and chemotherapeutic resistance. CD90+ TICs were isolated and characterized from ESCC clinical specimens as well as ESCC cell lines. In freshly resected clinical specimens, they represented a rare cell population, the levels of which correlated with strong family histories and lymph node metastasis. Our results prompt further study of this CD90+ population of esophageal TICs as potential therapeutic targets. Cancer Res; 73(7); 2322–32. ©2013 AACR.