Supplementary Figure 10 from Combined Targeting of NAD Biosynthesis and the NAD-dependent Transcription Factor C-terminal Binding Protein as a Promising Novel Therapy for Pancreatic Cancer

Dcona, M. Michael; Chougoni, Kranthi Kumar; Dcona, Diana T.; West, Jacqueline L.; Singh, Sahib J.; Ellis, Keith C.; Grossman, Steven R.

doi:10.1158/2767-9764.24243338.v1

crc-22-0521-s10.pdf (133.39 kB)

Supplementary Figure 10 from Combined Targeting of NAD Biosynthesis and the NAD-dependent Transcription Factor C-terminal Binding Protein as a Promising Novel Therapy for Pancreatic Cancer

journal contribution

posted on 2023-10-04, 14:20 authored by M. Michael Dcona, Kranthi Kumar Chougoni, Diana T. Dcona, Jacqueline L. West, Sahib J. Singh, Keith C. Ellis, Steven R. Grossman

Mean weight of mice in each of the 4 treatment cohorts from the xenograft study in Fig. 5

Funding

n/a

History

ARTICLE ABSTRACT

Effective precision therapies are lacking in PDAC. We demonstrate that simultaneous inhibition of NAD metabolism and the oncoprotein CtBP is potently effective at blocking growth of both PDAC cells in culture and human PDAC-derived tumors in mice and should be explored further as a potential therapy for patients with PDAC.

Usage metrics

Keywords

Metabolism Metabolic pathways Oncogenes & Tumor Suppressors Chemistry & Chemical Biology Small Molecule Agents Biomarkers Diagnostic biomarkers Drug Targets Gastrointestinal Cancers Pancreatic cancer

Licence

CC BY

Supplementary Figure 10 from Combined Targeting of NAD Biosynthesis and the NAD-dependent Transcription Factor C-terminal Binding Protein as a Promising Novel Therapy for Pancreatic Cancer

Funding

n/a

History

ARTICLE ABSTRACT

Usage metrics

Categories

Keywords

Licence

Exports