posted on 2023-04-04, 01:43authored byVerra M. Ngwa, Deanna N. Edwards, Yoonha Hwang, Breelyn Karno, Xiaoyong Wang, Chi Yan, Ann Richmond, Dana M. Brantley-Sieders, Jin Chen
This figure shows volcano plots of differentially expressed genes in GLSECKO versus WT endothelial cell, differentially enriched pathways up and down, Gene set enrichment analysis, -log FPKM of Gls, Gls2, angiogenic genes, qRT-PCR of leptin and angiogenic genes in GLSECKO versus WT.
Funding
HHS | NIH | National Cancer Institute (NCI)
Center for Integrated Healthcare, U.S. Department of Veterans Affairs (CIH, VA)
History
ARTICLE ABSTRACT
This study demonstrates a crucial role for glutamine metabolism in tumor endothelium, which may be exploited therapeutically to induce vascular normalization and improve drug delivery in solid tumors.