American Association for Cancer Research
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Supplementary Fig. S6 from Loss of Vascular Endothelial Glutaminase Inhibits Tumor Growth and Metastasis, and Increases Sensitivity to Chemotherapy

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posted on 2023-04-04, 01:43 authored by Verra M. Ngwa, Deanna N. Edwards, Yoonha Hwang, Breelyn Karno, Xiaoyong Wang, Chi Yan, Ann Richmond, Dana M. Brantley-Sieders, Jin Chen

This figure shows volcano plots of differentially expressed genes in GLSECKO versus WT endothelial cell, differentially enriched pathways up and down, Gene set enrichment analysis, -log FPKM of Gls, Gls2, angiogenic genes, qRT-PCR of leptin and angiogenic genes in GLSECKO versus WT.

Funding

HHS | NIH | National Cancer Institute (NCI)

Center for Integrated Healthcare, U.S. Department of Veterans Affairs (CIH, VA)

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ARTICLE ABSTRACT

This study demonstrates a crucial role for glutamine metabolism in tumor endothelium, which may be exploited therapeutically to induce vascular normalization and improve drug delivery in solid tumors.