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Supplementary Fig S2 from Development of an Automated Liquid Biopsy Assay for Methylated Markers in Advanced Breast Cancer

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posted on 2023-04-04, 01:24 authored by Mary Jo Fackler, Suzana Tulac, Neesha Venkatesan, Adam J. Aslam, Timothy N. de Guzman, Claudia Mercado-Rodriguez, Leslie M. Cope, Bradley M. Downs, Abdul Hussain Vali, Wanjun Ding, Jennifer Lehman, Rita Denbow, Jeffrey Reynolds, Morgan E. Buckley, Kala Visvanathan, Christopher B. Umbricht, Antonio C. Wolff, Vered Stearns, Michael Bates, Edwin W. Lai, Saraswati Sukumar

Figure shows the analytical sensitivity of LBx-BCM based detection of fully methylated DNA (0-300 copies) spiked into normal serum separately for each gene in the panel in 10-11 replicate assays

Funding

U.S. Department of Defense (DOD)

Cepheid (Cepheid Inc)

Avon Foundation for Women (AFW)

Susan G. Komen (SGK)

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ARTICLE ABSTRACT

We technically validated an automated, cartridge-based, liquid biopsy prototype assay, to quantitatively measure breast cancer methylation in serum or plasma of patients with MBC, that demonstrated high sensitivity and specificity.

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    Cancer Research Communications

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    Keywords

    Breast CancerLiquid BiopsyEpigeneticsDNA methylationBiomarkersSerum biomarkersEpigenetic biomarkersPrognostic biomarkersDiagnostic biomarkers

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    CC BY

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